What is CUMYL-CYBINACA or SGT-78 ?
CUMYL-4CN-BINACA (also known as CUMYL-CYBINACA or SGT-78) is an indazole-3-carboxamide based synthetic cannabinoid that has been sold online as a designer drug.
It is a potent agonist for cannabinoid receptors CB1 and CB2, with in vitro EC50 values of 0.58 nM and 6.12 nM, respectively.
In mice, CUMYL-4CN-BINACA produces hypothermic and pro-convulsant effects via the CB1 receptor,and anecdotal reports suggest it has an active dose of around 0.1 mg in humans.
CUMYL-4CN-BINACA is metabolized to produce cyanide, raising concerns about liver toxicity.There is one reported case of hyperthermia, rhabdomyolysis, and kidney failure associated with its use.
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Synthetic cannabinoids like SGT-78 have a fairly low specificity. However, they are powerful agonists of both the CB1 and CB2 receptors in test subjects.
SGT-78 is chemically similar to 5F-Cumyl-PINACA, except that the alkyl chain terminates in a cyano group. The extent to which this can metabolize into cyanide in living subjects is not fully understood.
This product should be stored in a dry, cool location, and should retain full potency for at least 2 years if stored properly.
CUMYL-4CN-BINACA or SGT-78 is an indazole-3-carboxamide based synthetic cannabinoid.
For instance, Has been sold online as a designer drug. Similarly, It is a potent agonist for cannabinoid receptors CB1 and CB2. Eventually, in vitro EC50 values of 0.58 nM and 6.12 nM, respectively. J
In mice, SGT-78 produces hypothermic and pro-convulsant effects via the CB1 receptor. Anecdotal reports suggest it has an active dose of around 0.1 mg in humans. SGT-78 is metabolized to produce cyanide.
Concerned Liver toxicity. Moreover, reported cases of hyperthermia, rhabdomyolysis, and kidney failure associated with its use.
Equally, Its an analytical reference standard that is structurally categorized as a synthetic cannabinoid similar to 5FAEB2201. Product intended for forensic and research applications.
To start with, Cannabis produces a variety compounds known as cannabinoid. Many absent in other plants. How many, exactly? It’s hard to say. You’ll often see people report that there are dozens, or even 100+ plant cannabinoids produced by cannabis. Likewise, it’s difficult to know the precise number. Finally, Most are present at very low levels, especially in commercial cannabis products. This makes it difficult for scientists to accurately detect them. The important point is that there are many.