Methylenedioxypyrovalerone (MDPV) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI).
It was first developed in the 1960s by a team at Boehringer Ingelheim.Its activity at the dopamine transporter is six
times stronger than at the norepinephrine transporter and it is virtually inactive at the serotonin transporter.
MDPV remained an obscure stimulant until around 2004 when it was reportedly sold as a designer drug.
In the USA, products containing MDPV and labeled as bath salts were sold as recreational drugs in gas stations, similar to the marketing for Spice and K2 as incense, until it was banned in 2011
3,4-Methylenedioxypyrovalerone (also known as MDPV and imprecisely as Bath Salts, among many others) is a
novel lesser-known stimulant substance of the cathinone and pyrrolidine classes. It is known to be one of the most
powerful and potent stimulants. MDPV is thought to act primarily as a norepinephrine-dopamine reuptake inhibitor (NDRI).
MDPV was first developed in the 1960s by a team at Boehringer Ingelheim. It was claimed to have potential to be
an alternative for racemic amphetamine and, despite showing some desirable qualities such as reduced toxicity as
compared to amphetamine, was chosen to not be developed as a medicinal drug.
MDPV remained an obscure stimulant until around 2004, when it was reportedly first made available to the public as
a designer drug. Products labeled as “bath salts” containing MDPV were previously sold as recreational drugs in gas
stations and convenience stores in the United States, similar to the marketing strategy of Spice and K2 as incense.
It is highly advised to use harm reduction practices if using this substance.
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