WHAT IS
JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors.
JWH 019
It is the N-hexyl homolog of the more common synthetic cannabinoid compound JWH-018.
Unlike the butyl homolog JWH-073, which is several times weaker than JWH-018, the hexyl homolog is only slightly less potent, although extending the chain one carbon longer to the heptyl homolog JWH-020 results in dramatic loss of activity.
These results show that the optimum side chain length for CB1 binding in the naphthoylindole series is the five-carbon pentyl chain, shorter than in the classical cannabinoids where a seven-carbon heptyl chain produces the most potent compounds.
This difference is thought to reflect a slightly different binding conformation adopted by the naphthoylindole
compounds as compared to the classical cannabinoids, and may be useful in characterizing the active site of the CB1 and CB2 receptors
JWH 019 is a cannabimimetic indole that shows a high-affinity for both the central cannabinoid (CB1) and the
peripheral cannabinoid (CB2) receptors. JWH-019 Full chemical name: 1-hexyl-3-(naphthalen-1-oyl)indole Other
names:1-hexyl-1H-indol-3-yl)-1-naphthalenyl-methanone, JWH-019 CAS number of substance: 209414-08-4 Physical properties:
Technical Information
- DMF: 30 mg/ml
- DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 5 mg/ml
Shipping & Storage Information
| JWH-019 (1-Hexyl-1H-indol-3-yl)-1-naphthalenyl-methanone |
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| (1-hexyl-1H-indol-3-yl)(naphthalen-1-yl)methanone | |
| Synthetic cannabinoids | |
| Synthetic cannabinoid receptor agonists | |
| 209414-08-4 | |
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InChI=1S/C25H25NO/c1-2-3-4-9-17-26-18-23(21-14-7-8-16-24(21)26)25(27)22-15-10-12-19-11-5-6-13-20(19)22/h5-8,10-16,18H,2-4,9,17H2,1H3
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PALJPGHWDUHUPO-UHFFFAOYSA-N
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CCCCCCN1C2=C(C(C(C3=C(C=CC=C4)C4=CC=C3)=O)=C1)C=CC=C2
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| C25H25NO | |
| 355.4721 g/mol |
JWH 019 N-(6-hydroxyhexyl) β-D-Glucuronide – 1 mg
JWH 019 (Item No. 13633) is a cannabimimetic indole that shows a high-affinity for both the central cannabinoid (CB1) (Ki = 9.8 nM) and the peripheral cannabinoid (CB2) (Ki = 5.6 nM) receptors.{16797} JWH 019 N-(6-hydroxyhexyl) β-D-Glucuronide is an expected major urinary metabolite of JWH 019, based on the metabolism of similar cannabimimetics.{18291,19353,20170} The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.
