4-MeO-PCP CRYSTAL, 4-Methoxyphencyclidine (methoxydine, 4-MeO-PCP) is a dissociative anesthetic drug that has been sold online as a research chemical.
The synthesis of 4-MeO-PCP was first reported in 1965 by the Parke-Davis medicinal chemist Victor Maddox. A 1999
review published by a chemist using the pseudonym John Q. Beagle suggested the potency of 4-MeO-PCP in man
was reduced relative to PCP, two years later Beagle published a detailed description of the synthesis and qualitative
effects of 4-MeO-PCP, which he said possessed 70% the potency of PCP.
4-MeO-PCP was the first arylcyclohexylamine research chemical to be sold online, it was introduced in late 2008 by a company trading under the name CBAY and was followed by several related compounds such as 3-MeO-PCP and methoxetamine.
4-MeO-PCP has lower affinity for the NMDA receptor than PCP, but higher affinity than ketamine, it is orally active
in a dosage range similar to ketamine, with some users requiring doses in excess of 100 mg for desired effects. Users
have reported substantial differences in active dose, these discrepancies can be partially explained by the presence of
unreacted PCC and other impurities in samples sold on the grey market. 4-MeO-PCP has Ki values of 404 nM for the
NMDA receptor, 713 nM for the norepinephrine transporter, 844 nM for the serotonin transporter, 296 nM for the? 1 receptor, and 143 nM for the ? 2 receptor.
4-MeO-PCP hydrochloride is a white crystalline solid with a melting point of 181-182 °C
Shipping & Storage Information
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: ? 2 years
- Formal Name: 1-[1-(4-methoxyphenyl)cyclohexyl]-piperidine, monohydrochloride
- CAS Number: 2185-93-5
- Purity: ?98%
- Formulation: A crystalline solid
- ?max: 231, 272 nm
- SMILES: COC(C=C1)=CC=C1C2(N3CCCCC3)CCCCC2.Cl
- InChi CodeInChI=1S/C18H27NO.ClH/c1-20-17-10-8-16(9-11-17)18(12-4-2-5-13-18)19-14-6-3-7-15-19;/h8-11H,2-7,12-15H2,1H3;1H
- InChi Key: FYAFJNVLHWQLHK-UHFFFAOYSA-N
4-MeO-PCP has caused a fatality in combination with 4-HO-MET, venlafaxine, olanzapine, lorazepam and hydroxyzine.
Chemical and physical
Molar mass: 273.420 g·mol?1
Good for research